Looking for some unique Southern girlfriend getaways?

Let’s face it. Not many girls trips make it out of the group chat. But when they do, they’re nothing short of magical. There’s something wonderful about hitting pause on daily life, packing a bag, and heading out for a girls weekend filled with laughter, good food, and unforgettable moments.

Whether your group is looking for a weekend in a bustling city or a relaxing retreat in a charming small town, these Southern towns promise to disconnect you from the stresses of life and reconnect you to the friends who feed your soul. Fair warning. We didn’t go with budget hotels or restaurants on this list. We picked places that would be as much of an experience as the city itself. But, feel free to adjust any of our suggestions to fit your budget.

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Southern Girlfriend Getaways to Book This Year

1. Charleston, South Carolina

Charleston is the epitome of Southern elegance and one of our favorite places to visit. I’ve written several articles on all the things there are to do in the Holy City. Thought it’s definitely a romantic city, it’s also the perfect place for girlfriends looking to blend history, luxury, and relaxation in one destination.

Book a room at the boutique Spectator Hotel, where 1920s glamour meets modern luxury. Plan a spa day at The Spa at Charleston Place, then head to King Street to shop the upscale boutiques and cute shops. Round out your day with seafood and Southern classics at Husk, a beautifully restored historic home turned restaurant. Take a private carriage ride through the historic district or a sunset sail around the harbor before hitting one of the city’s rooftop bars for cocktails.

Charleston Hotels for a Girlfriend Getaway

Hotel Bennett
This is the Charleston “wow” hotel—with a rooftop bar for sunset cocktails, a spa for pampering, and plenty of pretty corners that are basically made for Instagram.

The Restoration Hotel
Think boutique chic with a fun twist—this spot even offers “Girls Getaway” packages with things like candle-making classes and in-room spa treatments, so you don’t have to plan a thing.

Planters Inn
If you’re after Southern charm, this historic inn nails it—four-poster beds, cozy fireplaces, and a location that puts you right in the middle of the Market.

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2. Savannah, Georgia

Savannah is Charleston’s cousin to the south. Iconic squares and historic beauty may set a romantic scene for couples trips, but its also a great place for a fun weekend girls’ getaway. Stay at The Gastonian, a charming inn known for its intimate feel and Southern hospitality.

Spend your days exploring antique and boutique shops in the Savannah Historic District. Unwind with a custom facial at Glow Med Spa, then enjoy riverside dining at The Collins Quarter or happy hour cocktails at Artillery Bar. Take an evening walk along the river. For an added adrenaline rush, add a ghost tour to your itinerary.

Savannah Hotels for a Girlfriend Getaway

Hotel Bardo
Savannah’s newest showstopper. This reimagined mansion has a chic pool scene, a courtyard with European flair, and even a cooking school if your crew wants a hands-on experience between cocktails.

Perry Lane Hotel
With a rooftop pool, craft cocktails, and a stylish boutique vibe rooted in Savannah’s character, this is the kind of place where you’ll be tempted to spend the whole weekend.

The Alida Hotel
Set on the riverfront, The Alida pairs a lively rooftop bar with easy access to shops and restaurants, giving you the best of both relaxing downtime and nights out.

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3. Asheville, North Carolina

Asheville is a cool artistic town in the Blue Ridge Mountains known for its creative spirit and natural beauty. This Southern girlfriends getaway can be as active as you want. Spend the days hiking hundreds of trails through the mountains. Or, shop till you drop in downtown Ashville. Stay at the luxurious Omni Grove Park Inn, where you can relax in mountain-view rooms and enjoy the inn’s world-class subterranean spa with eucalyptus-infused steam rooms and mineral pools.

Spend the day browsing quirky boutiques and art galleries in the River Arts District, and treat yourselves to farm-to-table dining at Curate, known for its Spanish tapas. Whether hiking waterfalls in state parks or booking a private yoga class overlooking the Blue Ridge Mountains, Asheville offers a refreshing mix of luxury and adventure.

Asheville Hotels for a Girlfriend Getaway

The Flat Iron Hotel
A historic building turned boutique beauty, this spot feels stylish and a little unexpected, with city and mountain views that make the perfect backdrop for a girls’ trip.

The Windsor
Spacious suites with full kitchens and living rooms give you room to spread out, which makes it easy to relax, sip wine, and catch up after a day downtown.

The Omni Grove Park Inn & Spa
If you want full-on resort vibes, Grove Park delivers with mountain views, a world-class spa, and plenty of cozy spots to enjoy a cocktail together.

Blind Tiger Asheville
This boutique inn has a creative, homey feel with thoughtful details and a cozy atmosphere that makes staying in just as tempting as heading out.

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4. Blowing Rock, North Carolina

Blowing Rock’s idyllic mountain setting is a peaceful escape for girls weekends focused on quality time together. Cozy up at Blowing Rock Manor, a historic retreat that feels like a home away from home. Relax with a massage at Westglow Resort & Spa, then explore quaint boutiques and antique shops along Main Street. Enjoy upscale Southern cuisine at The Best Cellar, and take in stunning scenic views from The Blowing Rock or enjoy a wine tasting at Grandfather Vineyard.

Blowing Rock Hotels for a Girlfriend Getaway

The Embers Hotel
Right in the middle of town, The Embers pairs mountain views with a warm, stylish vibe and plenty of cozy spots to relax together.elves.

Chetola Resort
Right in town, this lakeside resort gives you plenty of options—cozy lodge rooms, a spa, an indoor pool, and trails just outside your door.

The Blowing Rock Manor
A boutique hotel on Main Street with spacious suites and a modern, polished feel that makes it easy to settle in and feel at home.

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5. Fairhope, Alabama

Even though we travel through Mobile, Alabama quite a bit, Fairhope wasn’t on our radar until a couple of years ago. And, after one stay, we are looking forward to going back. Fairhope’s adorable downtown and waterfront sunsets set the stage for a great place to relax and reconnect. Stay at the historic Grand Hotel Golf Resort & Spa, a Marriott Autograph property right on the Mobile Bay that’s been welcoming guests since 1847. Its a spot you may have never heard of, but the list of celebrity guests is extensive including the likes of Zac Brown, Bob Hope, George Bush, Robert DeNiro, and Bo Jackson.

Stroll through local restaurants, art galleries, and cute boutiques downtown. Or, for a more active trip, take a kayak tour of Mobile Bay. Then feast on fresh Gulf seafood at Panini Pete’s. End your day with dinner at our favorite seafood spot on the coast, Felix’s Fish Camp. Then, watch the sunset at the Fairhope Pier.

Fairhope Hotels for a Girlfriend Getaway

Grand Hotel Golf Resort & Spa
This classic Gulf Coast resort has pools, a spa, a private beach, and plenty of space to enjoy a weekend of pure relaxation with friends.

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6. Fredericksburg, Texas

We took a day trip to Fredericksburg when we were in San Antonio and I immediately knew it would be a great spot for a girls weekend. Fredericksburg is the wine region of Texas Hill Country and perfect for a sophisticated and leisurely girls’ trip. Stay at the charming Hoffman Haus, where Southern elegance meets modern comfort, and start your day with a luxurious treatment at Nature’s Spa at Hoffman Haus.

Spend your afternoons browsing boutique shops and antique stores along Main Street, followed by fine dining at Vaudeville, a French bistro with Texas flair. Of course, you’ll probably want to hit some of the wineries. We didn’t get to try them all, but our favorites were Becker Vineyards and Fat Ass Ranch & Winery. Don’t miss a hike at Enchanted Rock, for the breathtaking panoramic views. With its combination of award-winning wines and charming German-inspired shops, this Texas gem is one of the best trips for girl groups.

Fredericksburg Hotels for a Girlfriend Getaway

The Albert Hotel
One of the newest stays in town, The Albert mixes boutique style with plenty of perks like a spa, a bar, and a chef-driven restaurant, so you can treat yourselves without ever leaving the property.

Emigrant’s Inn
Just steps from Main Street, this cozy boutique inn feels historic and homey, with suites that give you space to spread out and enjoy slow mornings together.

Whitetail Court Hotel
With eight private cottages tucked behind a walled garden, this boutique stay feels like your own secret hideaway in town, complete with lovely courtyards and garden peace.

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7. St. Simons Island, Georgia

St. Simons Island, off Georgia’s southern coast, is the perfect destination for a girlfriends’ getaway. Book your stay at The King and Prince Beach & Golf Resort, for stunning oceanfront views and luxurious amenities.

Spend your mornings exploring the Pier Village for plenty of shopping, and enjoy a leisurely lunch at Georgia Sea Grill. In the afternoons, embark on a dolphin-watching tour or relax on the golden beaches. This beach town offers a great way to unwind and enjoy the company of your best gals.

St. Simons Island Hotels for a Girlfriend Getaway

The King and Prince Beach & Golf Resort
Right on the beach, this resort has pools, golf, and the only oceanfront restaurant on the island, so you can spend the whole weekend with your toes in the sand and a drink in hand.

Hotel Simone
This adults-only boutique hotel keeps it stylish and relaxed with all-suite rooms, a rooftop pool, and complimentary bikes for exploring the island.

Sea Palms Resort
Set back from the busy areas, Sea Palms has a laid-back feel with updated rooms, on-site dining, and a peaceful marshside setting that makes mornings linger a little longer.

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8. Beaufort, South Carolina

This charming small town boasts a delightful blend of history, natural beauty, and modern amenities. We make a stop here when we visit Hilton Head Island. Its a quiet, charming town that I think is perfect for Southern girlfriend getaways.

Stay at the historic Rhett House Inn, known for its old-world charm and Southern hospitality. Wander through the Civil War history preserved in its downtown, explore antique shops, and dine at Saltus River Grill. For an outdoor adventure, rent bikes to explore Hunting Island State Park or take a boat tour along the waterfront.

Beaufort Hotels for a Girlfriend Getaway

The Beaufort Inn
n the heart of downtown, this restored antebellum mansion has inviting courtyards and wide porches that make it easy to slow down with a glass of wine.

Rhett House Inn
Surrounded by live oaks, this historic home feels cozy and welcoming, with modern touches that make your stay comfortable and the shops and waterfront within walking distance.

Anchorage 1770
Set on the waterfront, this boutique inn has a rooftop bar with sweeping views and a restaurant that makes staying in as tempting as going out.

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9. Hot Springs, Arkansas

Hot Springs combines relaxation and adventure, making it an ideal spot for fun Southern girlfriend getaways. Check into the historic Arlington Resort Hotel & Spa, then rejuvenate with a mineral bath at Quapaw Baths & Spa.

Explore Bathhouse Row for a taste of history and good times, and indulge in craft brews and creative dishes at Superior Bathhouse Brewery. Outdoor enthusiasts will love hiking through Hot Springs National Park, while others can enjoy scenic drives or spa days.

Hot Springs Hotels for a Girlfriend Getaway

Hotel Hale
With just nine suites, this boutique hotel feels intimate and special, and the mineral soak tubs filled from the natural hot springs make it easy to relax the minute you arrive.

The Waters Hot Springs
Right on Bathhouse Row, The Waters blends historic charm with modern comfort, and its central location makes it easy to shop, dine, and explore without ever moving your car.

Lookout Point Lakeside Inn
Right on the lake, this inn offers beautiful water views, homemade breakfasts, and plenty of places to slow down and spend time together.

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10. Oxford, Mississippi

There’s nothing quite like an tailgating in The Grove. Picture full buffet spreads and crystal chandeliers hanging from pop up tents. While I love the energy of an Ole Miss football game, Oxford, MS is also a great place for a culturally rich and vibrant girlfriends’ getaway.

Stay at Graduate Oxford, where Southern charm meets modern comfort. Start your day exploring the famous Square Books and nearby antique shops. Have lunch at City Grocery and don’t miss live music performances at The Lyric Theater. For a little added culture, tour William Faulkner’s home, Rowan Oak.

Oxford Hotels for a Girlfriend Getaway

The Oliver Hotel
Just off the Square, this boutique hotel mixes Southern charm with modern comfort, and the speakeasy-style bar makes it easy to end the night together without leaving the property.

Graduate Oxford
Right on the Square, this playful hotel nods to local history while giving you cozy rooms, a rooftop bar with sunset views, and bikes to explore town at your own pace.

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11. St. Augustine, Florida

St. Augustine is the perfect place to enjoy old-world charm with great food and cool history, all right on the beach. Visit the Castillo de San Marcos, stroll the cobblestone streets of St. George Street, and explore its vibrant boutiques. Dine on fresh seafood at Florida’s oldest restaurant, Columbia Restaurant. Unwind after a day of sunbathing and shopping with a sunset cruise along the bay. The town’s historic ambiance and water sports offer something for every type of girlfriend getaway.

St. Augustine Hotels for a Girlfriend Getaway

The Collector Luxury Inn & Gardens
An adults-only inn made up of nine historic homes, The Collector has lush gardens, fountains, and a central location that makes exploring the old city simple and fun.

Bayfront Marin House
This colorful waterfront inn looks right out at Matanzas Bay and serves up homemade breakfast, daily happy hour, and free bikes for cruising along the seawall.

Casa Monica Resort & Spa
One of St. Augustine’s most iconic hotels, Casa Monica delivers Spanish-inspired style, a full spa, and plenty of spaces that make it easy to spend the day right on property.

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12. New Orleans, Louisiana

New Orleans is a vibrant mix of culture, music, and good food, making it one of the top picks for a gal pals escape. Splurge for a stay at the iconic Hotel Monteleone, home of the famous Carousel Bar that’s been New Orleans’ only rotating bar since 1949.

Start your day with beignets and cafe au lait at Cafe du Monde. Just remember the rule – don’t wear black. The powdered sugar is attracted to anything dark! Spend the afternoon shopping on Magazine Street or take a cooking class to master Creole classics. Wrap up your evening with live jazz at Preservation Hall and a cocktail at The Sazerac Bar.

New Orleans Hotels for a Girlfriend Getaway

Hotel Monteleone
In the middle of the French Quarter, this historic hotel is home to the famous Carousel Bar and offers plenty of charm along with comfortable, elegant rooms.

Virgin Hotels New Orleans
With a rooftop pool, stylish lounges, and chic rooms in a central location, this hotel is fun and modern while still giving you all the comfort you want for a girls’ weekend.

The Garden District Hotel
One of the city’s newest boutique hotels, this spot has modern rooms and a swim-up pool bar, giving you a fun and fresh way to enjoy a weekend in New Orleans.

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13. Florida Keys

For a laid-back, tropical-inspired getaway perfect for reconnecting with your best gals head to the Florida Keys. Stay at The Perry Hotel & Marina in Key West and enjoy water activities like snorkeling or paddleboarding.

Explore the shops and restaurants of Duval Street, then toast the sunset at Mallory Square. For dinner, head to Latitudes, a fine-dining spot on a private island. This fun weekend getaway is perfect for groups who love sunshine and adventure.

Florida Keys Hotels for a Girlfriend Getaway

H2O Suites – Adults Only (Key West)
An adults-only all-suite hotel just off Duval Street, H2O has a rooftop pool and plenty of space to relax after a night out in Key West.

Baker’s Cay Resort (Key Largo)
Set on a former pineapple plantation, this resort feels tucked away with quiet beaches, nature trails, and stylish rooms that balance comfort with character.

Amara Cay Resort (Islamorada)
A laid-back boutique resort with ocean views, water activities, and cozy corners that make doing nothing together feel like the best plan.

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Time to Plan Your Next Southern Girlfriends Getaway!

Life gets busy, and it’s easy to let time with friends fall to the wayside. But sometimes we need to step away from the daily grind and reconnect with our best friends. And, a charming Southern city is a great location.

Whether you’re sipping sweet tea on a shaded porch or toasting to new adventures over craft cocktails, these destinations are calling. So grab your calendar, rally the squad, and get ready to plan the ultimate trip to one of these incredible destinations.